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Open Access Hypothesis

Signaling pathway switch in breast cancer

Arnaud Guille, Max Chaffanet and Daniel Birnbaum*

Author Affiliations

Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, “Equipe labellisée Ligue Contre le Cancer”, UMR1068 Inserm, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Université, 27 bd. Leï Roure, BP 30059, Marseille 13273, France

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Cancer Cell International 2013, 13:66  doi:10.1186/1475-2867-13-66

Published: 27 June 2013

Abstract

Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells

Keywords:
Next generation sequencing; Breast cancer; Signaling pathways; Cell cycle; Kinases