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Effect of vanadium and beta-Carotene on the number of single-strand breaks/DNA fragment in rat liver 18–20 h after a single injection of DEN |
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| Group |
Treatment |
Percentage of Double-strand DNA |
Number of single-strand breaks/DNA fragment |
Inhibition (%) |
|
|
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| A |
Normal |
93.56 |
0.07 ± 0.02a |
|
| B |
DENA Control |
31.68 |
1.32 ± 0.01 b |
|
| C |
DENA+V |
47.23 |
0.58 ± 0.01 c |
56.06 |
| D |
DENA+BC |
52.87 |
0.54 ± 0.04 c |
59.09 |
| E |
DENA+V+BC |
64.73 |
0.48 ± 0.023 d |
63.6 |
|
The mean values of the number of the single-strand breaks/DNA fragment for Vanadium control (group c) was 0.07 ± 0.01; for β-carotene control (group d), 0.08 ± 0.01 and the Vanadium and beta-carotene control (group e), 0.10 ± 0.01. No statistical significance could be observed between these drug controls when compared with normal vehicle control (Group A). aValues are means ± S.E of 5 rats (each rat liver genomic was tested in triplicate) bp < 0.01 as compared with group A, cp < 0.01 as compared with group B, dp < 0.005 as compared with group B. | ||||
Chattopadhyay et al. Cancer Cell International 2005 5:16 doi:10.1186/1475-2867-5-16 |
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