|
Indices of cytotoxicity (IC50) to several cancer drugs founded in multicellular spheroids and monolayer. |
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| Drug |
Monolayers IC50 (μM) |
Multicell. spheroids IC50 (μM) |
||||
| INER-51 |
PCS-1 |
RR |
INER-51 |
PCS-1 |
RR |
|
|
|
||||||
| Doxorubicin |
6.2 |
9.2 |
1.4 |
15 |
9.8 |
0.6 |
| Etoposide |
2.2 |
4.1 |
1.8 |
>50 |
>50 |
---- |
| Methotrexate |
0.8 |
2.8 |
3.5 |
>50 |
>50 |
---- |
|
Drug exposition was continuous for 72 hours and drug cytotoxicity was performed by MTT assay. IC50: Fifty percent of the decrease in the survival rate. RR: The value of relative resistance of INER-51 cells vs PSC-1 cells as monolayers or multicellular spheroids. | ||||||
Valeria and Raúl Cancer Cell International 2005 5:20 doi:10.1186/1475-2867-5-20 |
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