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Gene locus and tissue distribution of ABC transporters |
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| Name |
Alternate name |
Gene locus |
Tissue distribution |
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| MDR1 |
ABCB1, P-GP |
7q36 [9] |
Gut (apical membrane), liver (canalicular membrane), kindey (apical membrane of epithelial cells of proximal tubule), blood brain barrier (luminal membrane of endothelial cells), testis (endothelial cells of capillary), placenta (trophoblast) |
| MRP1 |
ABCC1 |
16p13.1 [6] |
Many tissues (brain etc) |
| MRP2 |
ABCC2, cMOAT |
10q24 [10] |
Liver, gut, kidney, placenta |
| MRP3 |
ABCC3 |
17q21.3 [11] |
Liver, gut, adrenal cortex, placenta |
| MRP4 |
ABCC4 |
13q32 [11] |
Many tissues |
| MRP5 |
ABCC5 |
3q27 [11] |
Many tissues(brain etc) |
| MRP6 |
ABCC6 |
16p13.1 [12] |
Liver, kidney |
| MRP7 |
ABCC10 |
6p12-21 [13] |
Many tissues |
| MRP8 |
ABCC11 |
16q12.1 [14] |
Breast, testes |
| BCRP |
ABCG2, MXR1, ABCP |
4q22 [15] |
Placenta (syncytiotrophoblasts), intestine (epithelium), liver (canalicular membrane), breast (ducts and lobules), endometrium (vein and capillary but not artery), gut |
Choi Cancer Cell International 2005 5:30 doi:10.1186/1475-2867-5-30 |
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