Figure 5.

Effects of E5 variants assayed with EGF upon cell-cycle profiles. Results are expressed as the mean percentage (plus SEM) of cells in different stages of cell-cycling (G₀G₁, S & G₂M) for each of HPV-16 E5 variant tested (solid bars), HPV-6b E5 (diagonal stripes), 'stop' constructs (open bars). Numbers of experiments: 'stop', n = 21; HPV-6b, n = 6; HPV-16, n = 9; Thr⁶⁴, n = 9; Leu⁴⁴Val⁶⁵, n = 18; Thr³⁷ Leu⁴⁴Val⁶⁵, n = 6; and, Tyr⁸Leu⁴⁴Val⁶⁵, n = 11.