Figure 1.

In vitro growth inhibition by hydralazine, valproic acid and the combined treatment. Hydralazine had not growth inhibitory effects at the dose and conditions tested in none of the cell lines. Valproic acid induced a variable degree of inhibition in the cell lines. D54 glioma cell line had 80% growth inhibition whereas KB laryngeal carcinoma was the least but still inhibition was close to 50%. MCF-7 and SW480 were more sensitive to the combination of compounds although the difference was statistically significant only in SW480 cells (p < 0.001)