Figure 1.

PC-3M prostate cancer and metastasis. PC3M-luc cells (5 × 10⁵) were orthotopically injected into the prostate of Nu/Nu mice. Mice sacrificed at 50 days, prostate tumors were removed and prepared for sectioning. A. H&E section of orthotopic tumor [400×] mass. Normal glands (N), cancer cells (Ca) and mitotic figure (mit) are indicated. B. H&E section of tumor [200×] compressing normal glands. C. PCNA staining of PC-3M orthotopic tumor [630×]. D. Lymph node metastasis [200×] showing cancer cells (Ca) and lymphatic tissue (lym).