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uPAR overexpression enhances directional migration and in vitro invasion of PC-3M cells. |
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| migration |
invasion |
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|
|
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| uPAR transfected cells |
upper insert |
15.0 ± 3.0% |
20.0 ± 2.0% |
| lower insert |
29.4 ± 4.9% |
55.0 ± 12.0% |
|
| β-gal plasmid transfected (control) cells |
upper insert |
18.4 ± 3.2% |
14.5 ± 2.8% |
| lower insert |
16.1 ± 1.9% |
12.0 ± 1.5% |
|
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Table data indicate the percent uPAR+ or β-galactosidase+ cells in the population of cells on the upper membrane (general cell population) and lower membrane (cells which successfully traversed the membrane barrier) after a two day period. Data shows the mean and S.E.M of 3 replicate experiments. | |||
Sehgal et al. Cancer Cell International 2006 6:21 doi:10.1186/1475-2867-6-21 |
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