Stem cells, senescence, neosis and self-renewal in cancer

doi:10.1186/1475-2867-6-25

Cancer Cell International

Volume 6

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Stem cells, senescence, neosis and self-renewal in cancer

Rengaswami Rajaraman¹ , Duane L Guernsey² , Murali M Rajaraman³ and Selva R Rajaraman⁴

¹Department of Medicine, Division of Hematology, Dalhousie University, Halifax NS. B3H 1X5

²Department of Pathology, Dalhousie University, Halifax NS. B3H 1X5, Canada

³Nova Scotia Cancer Centre, Department of Radiation Oncology, QEII Health Sciences Center, Dalhousie University, Halifax NS. B3H 1X5, Canada

⁴Downtown Clinic, Windsor, ON, N9A 1G5, Canada

author email corresponding author email

Cancer Cell International 2006, 6:25doi:10.1186/1475-2867-6-25


Published:	8 November 2006

Additional files

Additional File 1:

Primary neosis in a tetraploid MN/PG formed by C3H10T1/2 cells on post-irradiation day 14.

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Additional File 2:

Neotic catastrophe in an MN/PG formed due to irradiation of C3H10T1/2 cells.

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Additional File 3:

Spontaneous S/T-neosis in HTB11 cells. The first half of the clip shows a Raju cell emerging from a cell lying vertical on the centre right of the frame. The second half shows the emergence of a Raju cell from the cell lying horizontal in the centre of the frame.

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Additional File 4:

Mitosis of a nascent Raju cell at the lower left of the frame.

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Additional File 5:

Raju cell maturing into tumor cell with increase in cell mass displays clonogenecity. A group of Raju cells of varying ages are increasing in cell mass and undergoing mitosis giving rise to a colony of the next generation of tumor cells at the right half of the fame.