Figure 9.

The percentage cleavage of oligonucleotide substrate containing 8-Oxo-dG lesion. The radiolabeled oligonucleotide substrate was incubated with cell extracts prepared from either unirradiated or 3 Gy irradiated cells collected at various time points. The reaction products were separated on polyacrylamide gel and the incised fragments were quantified to calculate the percentage cleavage at the 8-Oxo-dG site.