Role of stem cells in cancer therapy and cancer stem cells: a review

doi:10.1186/1475-2867-7-9

Cancer Cell International

Volume 7

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Sagar J
Chaib B
Sales K
Winslet M
Seifalian A

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Chaib B
Sales K
Winslet M
Seifalian A
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Review

Role of stem cells in cancer therapy and cancer stem cells: a review

Jayesh Sagar¹^,2 , Boussad Chaib² , Kevin Sales² , Marc Winslet¹^,2 and Alexander Seifalian¹^,2

¹Academic Department of Surgery, Royal Free Hospital, London, UK

²University College of London, London, UK

author email corresponding author email

Cancer Cell International 2007, 7:9doi:10.1186/1475-2867-7-9


Published:	4 June 2007

Abstract

For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from their use in the immuno-reconstitution, the stem cells have been reported to contribute in the tissue regeneration and as delivery vehicles in the cancer treatments. The recent concept of 'cancer stem cells' has directed scientific communities towards a different wide new area of research field and possible potential future treatment modalities for the cancer. Aim of this review is primarily focus on the recent developments in the use of the stem cells in the cancer treatments, then to discuss the cancer stem cells, now considered as backbone in the development of the cancer; and their role in carcinogenesis and their implications in the development of possible new cancer treatment options in future.