Figure 1.

Hierarchy of stem cells with cell determination, differentiation and maturation. It also shows potential areas of A. Trans-germal plasticity – differentiation from one stem to other stem cell type; B. De-differentiation – regression of a fixed lineage cell type to a more primitive cell type; C. Trans-determination – differentiation from one progenitor cells to another; and D. Trans-differentiation – hypothetical differentiation of one cell type to another without dedifferentiation.

Sagar et al. Cancer Cell International 2007 7:9   doi:10.1186/1475-2867-7-9
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