AP, addres and Affiliation from 2011 (Antonio Porcellini, 05 January 2012)
Note that from Dec 29 2010 the address of the author
was:
Antonio Porcellini,
University of Naples "Federico II"
Department of Structural and Functional Biology
Complesso Universitario di Monte Sant'Angelo
Via Cinthia
80126 Napoli, Italy
Email: antonio.porcellini@unina.it
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New Address (Antonio Porcellini, 19 December 2011)
My current address is: Università di Napoli Federico II Dipartimento di Biologia Strutturale e Funzionale Complesso Universitario di Monte Sant'Angelo Via Cinthia 80126 Napoli, Italy
The new e-mail address is: antonio.porcellini@unina.it
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Comment on the paper by: Rajaraman R, Guernsey DL, Rajaraman MM, Rajaraman SR. Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int 2006, Nov 8, 6:25. Is ‘neosis’ a novel type of cell division? Jekaterina ErenpreisaLatvian Biomedical Research and Studies Centre, Ratsupites 1,Riga, LV-1067, Latvia; katrina@biomed.lu.lvRegrowth of tumour from giant cells is now a focus of interest due to the hypothesis of ‘neosis’ based on several independent observations. Its authors [1, 2] claim neosis to be a novel cell division, the antithesis of mitotic catastrophe, and simultaneously an origin...
read full comment
After publication of this study. We lately discovered that due to an inadvertent and accidental mistake, our Primary research needs some important corrections; we profusely regret and offer our sincerest apologies and correct the text as under.1-in the Abstract: Tissue microarray containing malignant and normal breast tissues from 207 patients2- in the Background :The majority of invasive breast cancer arises from the epithelium of lobules and ducts of the glands (8-21)3- in the Methods : Fifty sex tissue cores were excluded from statistics because very little cancer cells or no breast cancer tissue were seen. The total number after exclusion was 244 tissue cores (37 matched tissues) of 207 patients.4-in the References :Change the reference number one with this reference:Victor G. Vogel....
read full comment
Comment on: Ismail et al. Cancer Cell International, 8:12
Excellent Research (Antoine Bake, 09 February 2007)
Comment on: Shehata Cancer Cell International, 5:10
Neosis: a unique approach (Denys Wheatley, 09 February 2007)
Comment posted by DNW (Editor CCI) on behalf of Dr Spencer:I find this article extremely interesting and a novel approach to the realm of cancer research. Too often we are stuck in a rut in terms of theories of how and why something happens, and it is essential that we should take a serious look into alternative ideas. Many times in history what seemed like an odd-ball idea or theory about a concept turned out in the end to be the absolute truth as we know and understand it today (e g. the idea that the sun goes round the earth). It behooves us to take seriously alternative views and ideas to seek the truth of a situation - and in the case of cancer, regarding the effect this disease has on humankind, I believe it is essential that we down any scenario that seems potentially useful in...
read full comment
The neosis idea unites chromosomal instability (CIN) concept with the role of polyploidy/aneuploidy and stem cancer cells' role in tumorigenesis (Denys Wheatley, 09 February 2007)
Comment (posted on behalf of Professor Sikora by DNW (editor CCI):The transforming events that allow cancer cells to develop are still not fully understood. A number of theories have been proposed. The most accepted view is that cancer results from the accumulation of inherited and somatic mutations in oncogenes and tumor suppressor genes. Mutations in those genes increase the proliferative potential of cells. It is believed that cancer cells are immortal, namely do not undergo senescence. However, the present paradigm is that, not only oncogenes, but also drugs or irradiation can induce senescence of cancer cells. Cancer cells that undergo in vitro senescence became giant and polyploidy and, as hitherto supposed, cease to proliferate. On the other hand, it is thought that polyploidy...
read full comment
Application of NK cells to T-Cell Non-Hodgkins Lymphoma (Matt Harrington, 09 February 2007)
Would this procedure be effective on patients with T-Cell Non-Hodgkins Lymphoma?
read full comment
Comment on: Uherek et al. Cancer Cell International, 4:S7
The editor (DNW) has edited 4 incoming comments on this paper and will post them for the four contributors concerned. (Denys Wheatley, 12 January 2007)
Re: Rajaraman et al.- Cancer Cell International 2006,6:25 ID: 246532Comment 1: I am a retired cell biology professor from University of New Brunswick, Canada. Even after my retirement I keep up with developments in the area of cell biology. Recently I read with interest an article "Hypothesis: Stem cells, senescence, neosis and self renewal in cancer" by Rajaraman et al. in the November 2006 papers in Cancer Cell International. It is a revolutionary hypothesis of cancer cell biology. This nicely written article is one of the best I have read this year and deserves to be recognized in this respect.P. Sivasubramanian psivasub@unb.caComment 2:Of future critical importance.I believe the calibre of this work provides a new benchmark for cancer research. It is an insightful new paradigm of...
read full comment
Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer. (Sergio Stagnaro, 21 December 2005)
I agree with the autors’s conclusions of this interesting paper (Himani Sharma, Archna Singh, et al. Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer Cancer Cell International 2005, 5:34 doi:10.1186/1475-2867-5-34). In fact, in previous articles, I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, both n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subjects involved by abnormalities of pschyco-neuro-endocrinological-immune system, i.e., in malignancy biological control system, I defined as Oncological Terrain (1-6). Really, both genetical and environmental...
read full comment
Comment on: Sharma et al. Cancer Cell International, 5:34
Two more references (Arno Knijn, 26 February 2005)
After reading the article, we were surprised to see that two articles published almost contemporarily in 2003, stating that rafts contribute to the mobile lipid proton NMR signals, are never mentioned. These articles are:1) Detergent-resistant membrane fractions contribute to the total 1H NMR-visible lipid signal in cells." Wright et al. European Journal of Biochemistry 270, 2091-2100 (2003) (article doi: 10.1046/j.1432-1033.2003.03586.x)2) "High-resolution proton NMR measures mobile lipids associated with Triton-resistant membrane domains in haematopoietic K562 cells lacking or expressing caveolin-1." Ferretti et al. European Biophysics Journal 32, 83-95 (2003) (article doi: 10.1007/s00249-002-0273-8)This absence is particularly evident for the article by Ferretti et al., since the...
read full comment
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Latest comments
AP, addres and Affiliation from 2011 (Antonio Porcellini, 05 January 2012)
Note that from Dec 29 2010 the address of the author
was:
Antonio Porcellini,
University of Naples "Federico II"
Department of Structural and Functional Biology
Complesso Universitario di Monte Sant'Angelo
Via Cinthia
80126 Napoli, Italy
Email: antonio.porcellini@unina.it read full comment
Comment on: Calogero et al. Cancer Cell International, 11:5
New Address (Antonio Porcellini, 19 December 2011)
My current address is:
Università di Napoli Federico II
Dipartimento di Biologia Strutturale e Funzionale
Complesso Universitario di Monte Sant'Angelo
Via Cinthia
80126 Napoli, Italy
The new e-mail address is: antonio.porcellini@unina.it read full comment
Comment on: Calogero et al. Cancer Cell International, 11:5
See below (Denys Wheatley, 12 February 2009)
Comment on the paper by: Rajaraman R, Guernsey DL, Rajaraman MM, Rajaraman SR. Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int 2006, Nov 8, 6:25. Is ‘neosis’ a novel type of cell division? Jekaterina ErenpreisaLatvian Biomedical Research and Studies Centre, Ratsupites 1,Riga, LV-1067, Latvia; katrina@biomed.lu.lvRegrowth of tumour from giant cells is now a focus of interest due to the hypothesis of ‘neosis’ based on several independent observations. Its authors [1, 2] claim neosis to be a novel cell division, the antithesis of mitotic catastrophe, and simultaneously an origin... read full comment
Comment on: Rajaraman et al. Cancer Cell International, 6:25
correction (nawfal ismail, 23 September 2008)
After publication of this study. We lately discovered that due to an inadvertent and accidental mistake, our Primary research needs some important corrections; we profusely regret and offer our sincerest apologies and correct the text as under.1-in the Abstract: Tissue microarray containing malignant and normal breast tissues from 207 patients2- in the Background :The majority of invasive breast cancer arises from the epithelium of lobules and ducts of the glands (8-21)3- in the Methods : Fifty sex tissue cores were excluded from statistics because very little cancer cells or no breast cancer tissue were seen. The total number after exclusion was 244 tissue cores (37 matched tissues) of 207 patients.4-in the References :Change the reference number one with this reference:Victor G. Vogel.... read full comment
Comment on: Ismail et al. Cancer Cell International, 8:12
Excellent Research (Antoine Bake, 09 February 2007)
finally a research I can Understand read full comment
Comment on: Shehata Cancer Cell International, 5:10
Neosis: a unique approach (Denys Wheatley, 09 February 2007)
Comment posted by DNW (Editor CCI) on behalf of Dr Spencer:I find this article extremely interesting and a novel approach to the realm of cancer research. Too often we are stuck in a rut in terms of theories of how and why something happens, and it is essential that we should take a serious look into alternative ideas. Many times in history what seemed like an odd-ball idea or theory about a concept turned out in the end to be the absolute truth as we know and understand it today (e g. the idea that the sun goes round the earth). It behooves us to take seriously alternative views and ideas to seek the truth of a situation - and in the case of cancer, regarding the effect this disease has on humankind, I believe it is essential that we down any scenario that seems potentially useful in... read full comment
Comment on: Rajaraman et al. Cancer Cell International, 6:25
The neosis idea unites chromosomal instability (CIN) concept with the role of polyploidy/aneuploidy and stem cancer cells' role in tumorigenesis (Denys Wheatley, 09 February 2007)
Comment (posted on behalf of Professor Sikora by DNW (editor CCI):The transforming events that allow cancer cells to develop are still not fully understood. A number of theories have been proposed. The most accepted view is that cancer results from the accumulation of inherited and somatic mutations in oncogenes and tumor suppressor genes. Mutations in those genes increase the proliferative potential of cells. It is believed that cancer cells are immortal, namely do not undergo senescence. However, the present paradigm is that, not only oncogenes, but also drugs or irradiation can induce senescence of cancer cells. Cancer cells that undergo in vitro senescence became giant and polyploidy and, as hitherto supposed, cease to proliferate. On the other hand, it is thought that polyploidy... read full comment
Comment on: Rajaraman et al. Cancer Cell International, 6:25
Application of NK cells to T-Cell Non-Hodgkins Lymphoma (Matt Harrington, 09 February 2007)
Would this procedure be effective on patients with T-Cell Non-Hodgkins Lymphoma? read full comment
Comment on: Uherek et al. Cancer Cell International, 4:S7
The editor (DNW) has edited 4 incoming comments on this paper and will post them for the four contributors concerned. (Denys Wheatley, 12 January 2007)
Re: Rajaraman et al.- Cancer Cell International 2006,6:25 ID: 246532Comment 1: I am a retired cell biology professor from University of New Brunswick, Canada. Even after my retirement I keep up with developments in the area of cell biology. Recently I read with interest an article "Hypothesis: Stem cells, senescence, neosis and self renewal in cancer" by Rajaraman et al. in the November 2006 papers in Cancer Cell International. It is a revolutionary hypothesis of cancer cell biology. This nicely written article is one of the best I have read this year and deserves to be recognized in this respect.P. Sivasubramanian psivasub@unb.caComment 2:Of future critical importance.I believe the calibre of this work provides a new benchmark for cancer research. It is an insightful new paradigm of... read full comment
Comment on: Rajaraman et al. Cancer Cell International, 6:25
Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer. (Sergio Stagnaro, 21 December 2005)
I agree with the autors’s conclusions of this interesting paper (Himani Sharma, Archna Singh, et al. Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer Cancer Cell International 2005, 5:34 doi:10.1186/1475-2867-5-34). In fact, in previous articles, I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, both n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subjects involved by abnormalities of pschyco-neuro-endocrinological-immune system, i.e., in malignancy biological control system, I defined as Oncological Terrain (1-6). Really, both genetical and environmental... read full comment
Comment on: Sharma et al. Cancer Cell International, 5:34
Two more references (Arno Knijn, 26 February 2005)
After reading the article, we were surprised to see that two articles published almost contemporarily in 2003, stating that rafts contribute to the mobile lipid proton NMR signals, are never mentioned. These articles are:1) Detergent-resistant membrane fractions contribute to the total 1H NMR-visible lipid signal in cells." Wright et al. European Journal of Biochemistry 270, 2091-2100 (2003) (article doi: 10.1046/j.1432-1033.2003.03586.x)2) "High-resolution proton NMR measures mobile lipids associated with Triton-resistant membrane domains in haematopoietic K562 cells lacking or expressing caveolin-1." Ferretti et al. European Biophysics Journal 32, 83-95 (2003) (article doi: 10.1007/s00249-002-0273-8)This absence is particularly evident for the article by Ferretti et al., since the... read full comment
Comment on: Mannechez et al. Cancer Cell International, 5:2